De Caridi G, Massara M, Acri I Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: a clinical study. Int Wound J. 2016; 13:(5)754-758

Khunger N Regenerative medicine in aesthetic surgery: hope or hype?. 2014; 7:(4)187-188

Khan ALondon (UK): CRC Press; 2021

Park KY, Seok J, Rho NK, Kim BJ, Kim MN Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients. Dermatol Ther. 2016; 29:(1)37-40

Stagni C, Rocchi M, Mazzotta A Randomised, double-blind comparison of a fixed co-formulation of intra-articular polynucleotides and hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis: two-year follow-up. BMC Musculoskelet Disord. 2021; 12;22:(1)

Introducing polynucleotides

02 December 2022
Volume 11 · Issue 10


Nurse prescriber Anna Kremerov details the science behind this revolutionary branch of regenerative medicine

Removing wrinkles, contouring and volumising aesthetic concerns are, of course, effective techniques to rejuvenate the face, but poor skin quality can mean that results are not always as impressive as they could be.

Most practitioners will also find that they often have a cohort of patients who do not need anything other than skin optimisation treatments, so it would be unethical to treat them with products that will not have the desired effect. However, turning them away when the practitioner has no solution does not feel great either.

While powerful devices such as radiofrequency and laser can boost collagen and elastin production to enhance the skin's appearance, they require an expensive investment of money and time. Of course, great skincare can make a difference, but committing to a routine requires dedication from the patient and, generally, slower results. So, this year, the author began researching alternatives.

Literature reviews and conference sessions led to an interest in regenerative medicine. One study defines this as an ‘interdisciplinary field of research and clinical applications focused on the repair, replacement or regeneration of cells, tissues or organs to restore impaired function resulting from any cause, including congenital defects, disease, trauma and ageing’ (Khunger, 2014).

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