A literature review on polynucleotide efficacy on skin rejuvenation, and review of the regulatory status and guidelines around polynucleotides

Despite the increasing use of polynucleotides, there exists a disparity in comprehensive regulatory guidelines, which raises concerns about standardisation and safety in clinical practice. This review calls for the establishment of robust, evidence-based regulatory standards that would ensure safe and effective application, aligning with international best practices.

To propel the field of aesthetic medicine forward, this study emphasises the necessity for continued research to validate the long-term efficacy and safety of polynucleotide treatments. It advocates for larger, randomised controlled trials to better understand the full scope of their therapeutic benefits and side effects. The integration of detailed mechanistic studies would also refine application protocols and enhance treatment outcomes.

Conclusively, while polynucleotides present a promising avenue for non-invasive rejuvenation therapies, their full integration into clinical practice demands a concerted effort to develop standardised guidelines and conduct comprehensive clinical evaluations. Such advancements will not only bolster the therapeutic repertoire of aesthetic medicine but also enhance patient safety and treatment efficacy, establishing a new standard in skincare treatment.