References
Profhilo Structura for skin rejuvenation

Abstract
Profhilo Structura, a skin treatment by IBSA Derma, uses stabilised hybrid cooperative complexes (HCCs) of high and low molecular weight hyaluronic acid (HA) to enhance skin hydration, firmness and texture. This case study examines its effects on a 54-year-old female with sun damage, dyschromia, and lower face skin laxity. Treatment plan: two sessions of Profhilo Structura were performed, spaced four weeks apart, targeting skin laxity and sagging in the lower face. The patient, classified as a ‘sagger’, sought to improve firmness without dermal filler use. Methods: a 22-gauge cannula was used to administer the product along the zygomatic arch and pre-auricular area. The treatment was minimally uncomfortable, rated at 2/10 (NRS).
In recent months, I have integrated Profhilo Structura, a newly launched skin treatment created by IBSA Derma into my practice. Profhilo Structura uses stabilised hybrid cooperative complexes (HCCs) of high and low molecular weight hyaluronic acid (HA) to promote bio-remodeling (Vassallo et al, 2024). This treatment is unique in its ability to both lift and firm skin while enhancing hydration levels (Humzah et al, 2024; Sparavigna et al, 2024). Over the past few months, I've treated multiple patients with this innovative product, and I am eager to share my observations and insights on its impact on skin laxity, patient selection, and overall treatment outcomes.
This case study focuses on one of my initial patients treated with Profhilo Structura. The patient is a 54-year-old female with Fitzpatrick skin type II, presenting with mild sun damage and facial dyschromia, as well as mild to moderate laxity in her lower face. Nine months prior, she had undergone a comprehensive facial rejuvenation with dermal fillers, which effectively enhanced her facial contours and provided volume where needed. However, with little additional improvement possible through fillers at this stage, her primary concern now was the residual sagging to the lower face, which had become more noticeable recently.
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