Cavallini M, Bartoletti E, Maioli L Consensus report on the use of PN-HPT™ (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021; 20:(3)922-928

Cavallini M, De Luca C, Prussia G PN-HPT® (Polynucleotides Highly Purified Technology) in facial middle third rejuvenation. Exploring the potential. J Cosmet Dermatol. 2022; 21:(2)615-624

Colangelo MT, Govoni P, Belletti S Polynucleotide biogel enhances tissue repair, matrix deposition and organization. J Biol Regul Homeost Agents. 2021; 35:(1)355-362

The introduction of polynucleotides

02 June 2023
Volume 12 · Issue 5


With polynucleotides being brought to the forefront in the aesthetics sector, editorial board member Alexandra Mills talks about their mechanisms, impact and versatility

The introduction of polynucleotide-based therapy into the cosmetic/aesthetic arena heralds a significant step in the way in which practitioners are now able to bio-revitalise and bio-rejuvenate a patient's skin in a significant and longer-lasting manner.

The basic unit of the polynucleotide-based injectable relies on long chains of highly purified nucleotides which form a series of highly stable alpha helixes. The hypoallergenic polynucleotides are contained within a non-hyaluronic acid clear gel carrier.

What about its mechanisms? Once injected intra-dermally, the high-purity polynucleotides target the dermal fibroblast to reduce levels of local free radicals, increase the synthesis of collagen and elastin appreciably, increase hydration through attracting water molecules local to the injection site and increase the viability of the targeted fibroblasts (Colangelo et al, 2021).

The overall impact clinically of high-purity polynucleotides when administered in skin is an improvement in intrinsic skin quality, with increased skin glow, reduction in pore size, improved smoothness, greater elasticity, improved humectant capacity and skin turgor. The treatment can be applied to patients who require skin maintenance, skin rescue and repair, wound healing, scar improvement and revision, reduced inflammation and importantly, skin ageing. Whether a patient has normal or sensitive skin, protocols have been devised through extensive research and peer-review that allow polynucleotides to be effective and well tolerated in either clinical situation (Cavallini et al, 2021; Cavallini et al, 2022).

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